Historical aspects of sarcoidosis

The historical aspects of sarcoidosis.

Immune aspects of sarcoidosis.

Although the initiating factor(s) is unknown, it is now accepted that pulmonary sarcoidosis develops as a result of an over-stimulated local cellular immune response. Starting as a lymphocytic alveolitis, there is a progression to granuloma formation within the interstitium as stimulated T lymphocytes release mediators capable of attracting and activating monocytes to differentiate into macroph...

Genetic aspects in sarcoidosis.

Sarcoidosis is an immune-mediated, multiorgan, granulomatous disorder thought to be triggered by an intricate combination of environmental and genetic factors. Two robust lines of evidence support the hypothesis of a genetic component in the pathogenesis of sarcoidosis: racial variation in its epidemiology and familial clustering of cases. The relationship between epidemiology and environmental...

Historical aspects of anxiety

"Anxiety" is a key term for behavioral, psychoanalytic, neuroendocrine, and psychopharmacological observations and theories. Commenting on its historical aspects is difficult, since history is properly a study of primary data. Unfortunately, much clinical anecdote does not correspond to factual records of a long time ago. Even reports of objective studies may suffer from allegiance effects. Thi...

Historical aspects of migraine.

The student of medicine first encountering the migraine literature will immediately perceive the extraordinary amount written, and will sense an unspoken frustrated fascination-a sort of blighted curiosity which pervades many accounts and descriptions. Enlightened self interest may explain some of the attention shown by physicians, since the incidence in our profession is as high as 30%. It is ...